A yellow “be aware” weather warning has been issued for Friday in parts of Tayside and Fife.
Snow is forecast in parts of North Fife, Dundee and Angus, starting from midnight and remaining until 3pm.
The Met Office said: “A spell of persistent and at times heavy snow is expected for parts of eastern Scotland starting Thursday night and lasting into Friday.
“Accumulations of 5-10 cm are likely above about 100m with 20cm or more possible above 200m, where drifting of snow in strong winds could be an additional hazard.
“At lower levels and near coasts an uncertain mix of rain and snow is expected, with rain likely to predominate, bringing the risk of standing water on roads.
“Please be aware of the risk of dangerous driving conditions and disruption to transport.”
The Met Office has advised that the warning will be kept under review, and updated throughout the day.
A yellow “be aware” warning means that commuters can expect minor disruptions on routes affected by weather.