The alarm was raised shorty after 10pm on Friday evening amid reports of a blaze at a building on the site.
Huge plumes of smoke were visible, with a police cordon in place at Nobel Road, Wade Street and Arrol Street.
Police assisting Scottish Fire and Rescue Service personnel immediately closed Nobel Road, Wade Street and Arrol Street.
Fire crews from Blackness Road and Kingsway stations tried to bring the blaze under control.
A spokesperson for Scottish Fire and Rescue Service, said: “Two appliances as well as a height vehicle are still in attendance as crews continue at the scene.”
Fire crews battle blaze at Dundee industrial estate