Emergency services were at a two-vehicle crash on the A9 at Auchterarder.
The crash happened just after noon on Sunday.
The northbound road was closed for around an hour and a half but has since re-opened.
Scottish Fire and Rescue Service sent two appliances to the scene.
It is not yet known if there are any casualties.
A spokesperson for SFRS said: “We got reports of a two-vehicle crash on the A9 at Auchterarder at 12.04pm.
“We sent two appliances from Auchterarder and Crieff at the scene.
“We have no further details at this stage.”
A Police Scotland spokesperson said: “Around 11.55am on Sunday police were called to a two-vehicle road crash northbound on the A9 at Auchterarder.
“Traffic was diverted via Auchterarder.
“Emergency services were at the scene and enquiries are continuing.”
Emergency services are also at a collision on the A9 at Pitlochry.
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