Fire crews from Pitlochry, Dunkeld and Kirkmichael were called to a house blaze on Friday evening.
The alarm was raised around 6.20pm following the outbreak at a two-storey modern home in the Rannoch area.
Scottish Fire and Rescue Service said three main jets were being used to deal with the fire.
No further details are available at this stage, but no-one is thought to have been injured in the incident.