The A9 was closed at Drumochter for over five hours following an accident involving a BEAR Scotland gritter.
The incident took place just after 2pm and closed the trunk road in both directions.
The road reopened northbound shortly before 7.30pm, with traffic allowed back on the southbound direction before 9pm.
Emergency services were called to the scene between Wade Bridge and Dalnacardoch Lodge. It is understood no-one was seriously injured in the crash but the Scottish Ambulance Service confirmed paramedics had been sent to the scene.
Pictures from the Traffic Scotland website show the route has been hit by heavy snow.
Two minor one-vehicle accidents happened nearby at Dalwhinnie, police said.
Motorists travelling to and from the Highlands were warned to expect long delays as a result of the closure.
Snow and blizzard conditions are badly affecting other parts of the A9 and police have advised drivers to take extra care.
The Met Office earlier issued yellow “be aware” warnings of snow and ice for much of the country lasting into Saturday.
Accumulations of 2cm to 5cm were expected on ground above 200 metres, with up to 10cm falling on higher routes above 300 metres, forecasters said.
Gale-force winds are also forecast to hit Shetland overnight with gusts of up to 80mph expected.
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