One in four jobs in Dundee could be lost by 2030 because of automation and globalisation.
The latest Centre for Cities report predicts a fifth of jobs across all British cities could by lost by 2030, with retail, customer service and warehouse posts said to be among the most at risk.
Cities including Mansfield, Sunderland and Wakefield could see two out of five jobs lost, while Oxford and Cambridge face losing 13%, the study found.
Dundee was the only Scottish location to make the top 10 of British cities most at risk.
In contrast, Edinburgh was among the top 10 least likely list, with a prediction that 19% of roles within the Scottish capital would go by 2030 as a result of automisation and globalisation.
The overall British average was 21%.
The report said the changes would lead to jobs being created as well as lost, but there was concerns over a North / South divide in relation to the quality of posts created.
Up to one in 10 jobs are in occupations predicted to grow, while new industries would bring positions which do not currently exist, it was predicted.
“Automation and globalisation will bring huge opportunities to increase prosperity and jobs, but there is also a real risk that many people and places will lose out,” Andrew Carter, chief executive of Centre for Cities, said.
“That means reforming the education system to give young people the cognitive and interpersonal skills they need to thrive in the future, and improving school standards, especially in places where jobs are most at risk.
“We also need greater investment in lifelong learning and technical education to help adults adapt to the changing labour market, and better retraining for people who lose their jobs because of these changes.
“The challenges and opportunities ahead for Blackburn are very different to those for Brighton.
“The Government needs to give cities more powers and resources to tackle the issues that automation and globalisation will present, and to make the most of the benefits they will bring.”