When the two met at Myreside last October, Dundee snatched a 42-37 win over current BT National 1 leaders Watsonians.
They will have to prevail again at Mayfield on Saturday to maintain a challenge for a promotion spot by right or in the second place play-off.
Dundee are on 49 points and lead Jed only on differential.
With bottom side Peebles at Marr, the Troon outfit who lie in second could extend their eight- point lead unless Dundee pick up a five-pointer.
Although Howe of Fife have dropped to sixth, they are a lot better placed than tomorrow’s opponents Aberdeen Grammar Rugby.
Defeat for Aberdeen GR at Rubislaw could be a nail in their relegation coffin.
Meanwhile, Kirkcaldy have hauled themselves up to sixth spot in BT National Division 3.
However, they have a huge task at home tomorrow against League leaders Hamilton.
The Laigh Bent crew handed out an awful 98-14 tanking to Kirkcaldy when they pitched up in Lanark, so it will not be the easiest of afternoons at Beveridge Park.
At North Inch, Perthshire take on a Dumfries side who are third in the table but who have games in hand.
Having harboured hopes of a promotion challenge early in the season, Shire have almost certainly left themselves too much to do in the games they have left, but it will be a matter of pride to turn over the 22-9 defeat at Park Farm back in October.